Description

3,4,5-Trifluorophenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing trifluoromethyl or fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluorophenyl moiety can enhance biological activity and metabolic stability.
• Ligand & Catalyst Development: Employed in the creation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Material Science Research: Serves as a monomer or building block for synthesizing organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	3,4,5-Trifluorophenylboronic Acid, Pinacol Ester
CAS No.	827614-70-0
Molecular Formula	C12H14BF3O2
Molecular Weight	258.05 g/mol
Synonyms	3,4,5-Trifluorophenylboronic Acid Pinacol Ester; 2-(3,4,5-Trifluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol 3,4,5-Trifluorophenylboronate; 3,4,5-Trifluorophenyl-Bpin; (3,4,5-Trifluorophenyl)boronic Acid Pinacol Ester; B-(3,4,5-Trifluorophenyl)boronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorophenylboronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.