Description

3,3-Difluoro-Cyclobutane-1,1-Dicarboxylic Acid is a high-value, multifunctional cyclobutane derivative featuring two carboxylic acid groups and two fluorine atoms on a strained ring system. This unique structure makes it a critical advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry and materials science. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used as a building block for creating new herbicides and pesticides with enhanced properties.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer & Material Science: Incorporated into specialty polymers to modify thermal stability, solubility, and electronic properties.
• Fluorine Chemistry Research: Essential for studying the effects of fluorine substitution and the strained cyclobutane ring on molecular conformation and reactivity.
• Peptidomimetics: The dicarboxylic acid moiety allows it to mimic amino acid backbones in the design of peptide analogs.

Basic Information

Product Name	3,3-Difluoro-Cyclobutane-1,1-Dicarboxylic Acid
CAS No.	827032-80-4
Molecular Formula	C6H6F2O4
Molecular Weight	180.11 g/mol
Synonyms	3,3-Difluorocyclobutane-1,1-dicarboxylic acid; 1,1-Cyclobutanedicarboxylic acid, 3,3-difluoro-; 3,3-Difluoro-1,1-cyclobutanedicarboxylic Acid; 827032-80-4; 3,3-Difluorocyclobutane-1,1-dioic Acid; DFCDA; 3,3-Difluorocyclobutan-1,1-dicarboxylic Acid
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-Cyclobutane-1,1-Dicarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.