Description

Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-Eddnp is a synthetic, sequence-specific peptide substrate designed for high-precision biochemical research and diagnostic applications. Its core value lies in its role as a highly selective tool for studying and quantifying the activity of specific proteolytic enzymes, such as furin and other proprotein convertases. This compound is essential for researchers and developers in the fields of pharmaceutical discovery, proteomics, and in vitro diagnostics, where understanding enzyme kinetics and substrate specificity is critical.

Application

• Enzyme Activity Assays: Primary substrate for measuring the catalytic activity of furin and related proprotein convertases in research settings.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize potential inhibitors of target proteases.
• Biochemical Research: Fundamental tool for studying enzyme kinetics, substrate specificity, and cleavage mechanisms in academic and industrial laboratories.
• Diagnostic Kit Development: Key component in the development of fluorogenic or colorimetric assay kits for clinical and research diagnostics.
• Proteomics Studies: Employed to investigate protease signaling pathways and protein processing events in cellular systems.
• Quality Control in Biologics: Used to monitor and ensure the consistency of enzymatic processes in biomanufacturing.

Basic Information

Item	Detail
Product Name	Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-Eddnp
CAS No.	824405-61-0
Molecular Formula	C66H102N22O19S
Molecular Weight	1499.71 g/mol
Synonyms	Abz-APQEEIMRRQ-EDDnp; Furin Substrate Abz-APQEEIMRRQ-EDDnp; 2-Aminobenzoyl-Ala-Pro-Gln-Glu-Ile-Met-Arg-Arg-Gln-(N-(2,4-Dinitrophenyl)ethylenediamine); Fluorogenic Furin Substrate; PACE4 Substrate; Proprotein Convertase Substrate; PC Substrate; Abz-APQEEIMRRQ-Eddnp
EINECS	Contact for details

Quality Control

Our Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-Eddnp is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (on dry basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.