Description

Monocyte Chemotactic Protein-1 (65-76) (Human) is a synthetic peptide fragment corresponding to a specific region of the full-length MCP-1 (CCL2) chemokine. This compound is a critical research tool for studying the role of MCP-1 in inflammatory processes, immune cell recruitment, and related disease pathways. It is primarily utilized by researchers and developers in the fields of immunology, oncology, and drug discovery for in vitro and in vivo studies, including receptor binding assays, functional antagonism, and mechanistic investigations.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of chemokine biology, signal transduction, and leukocyte migration.
• Drug Discovery & Development: Serves as a key reagent for screening and characterizing potential therapeutic compounds targeting the CCR2 receptor pathway.
• Inflammation Models: Applied in cellular assays and animal models to investigate the mechanisms of chronic inflammatory diseases such as atherosclerosis, rheumatoid arthritis, and neuroinflammation.
• Cancer Research: Employed to study the role of tumor-associated macrophages (TAMs) and the tumor microenvironment in cancer progression and metastasis.
• Assay Development & Validation: Acts as a critical component in the development and quality control of ELISA kits, cell-based chemotaxis assays, and other diagnostic or research tools.
• Academic & Pharmaceutical R&D: Essential for basic scientific research and pre-clinical development phases within university laboratories and pharmaceutical companies.

Basic Information

Product Name	Monocyte Chemotactic Protein-1 (65-76) (Human)
CAS No.	823814-33-1
Molecular Formula	C58H95N19O19S
Molecular Weight	1370.6 g/mol
Synonyms	MCP-1 (65-76); CCL2 (65-76); Chemokine (C-C motif) ligand 2 fragment 65-76; Human MCP-1(65-76); Monocyte Chemoattractant Protein-1 (65-76); Peptide MCP-1 (65-76); MCAF (65-76); GDCF-2 (65-76); HC11; SMC-CF (65-76)
EINECS	Contact for details

Quality Control

Every batch of Monocyte Chemotactic Protein-1 (65-76) (Human) is manufactured and analyzed under stringent quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure high purity, precise amino acid sequence, and biological activity. Certificates of Analysis (COA) detailing purity, HPLC profile, mass spectrometry (MS) data, and endotoxin levels are available upon request to support your research compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below. This product is hygroscopic (moisture-sensitive). Solutions should be prepared in appropriate buffers and used immediately or aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Consistent with reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Molecular Weight (MS)	1370.6 ± 1.0 Da
Water Content (KF)	≤ 5.0%
Endotoxin Level (LAL)	< 1.0 EU/mg
Biological Activity (Cell Migration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.