Description

(R)-(+)-1-[(R)-2-(2'-Dicyclohexylphosphinophenyl)Ferrocenyl]Ethylbis(3,5-Trifluoromethylphenyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand designed for asymmetric catalysis. This compound matters because it provides exceptional enantioselectivity and catalytic activity in critical transition-metal-catalyzed reactions, enabling the synthesis of complex, single-enantiomer molecules. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require high-performance ligands for creating chiral intermediates and active pharmaceutical ingredients (APIs).

Application

This advanced chiral ligand is a cornerstone in modern asymmetric synthesis, finding critical use in:

• Asymmetric Hydrogenation: A key catalyst for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer building blocks for APIs, where chirality is crucial for biological activity and safety.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and insecticides to enhance efficacy and reduce environmental impact.
• Cross-Coupling Reactions: Facilitates asymmetric C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, with high stereocontrol.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel synthetic routes to complex molecules.
• Fine Chemical Production: Applied in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	(R)-(+)-1-[(R)-2-(2'-Dicyclohexylphosphinophenyl)Ferrocenyl]Ethylbis(3,5-Trifluoromethylphenyl)Phosphine
CAS No.	821009-34-1
Molecular Formula	C51H51F6FeP2
Molecular Weight	880.72 g/mol
Synonyms	(R)-(+)-1-[(R)-2-(2'-Dicyclohexylphosphinophenyl)Ferrocenyl]Ethylbis(3,5-Trifluoromethylphenyl)Phosphine; Josiphos SL-J009-1; (R)-1-[(S)-2-(2'-Dicyclohexylphosphino)phenyl]ferrocenyl]ethyldi(3,5-trifluoromethyl)phenylphosphine; SL-J009-1; Josiphos ligand J009-1; (R)-1-((S)-2-(Dicyclohexylphosphino)ferrocenyl)ethyldi(3,5-bis(trifluoromethyl)phenyl)phosphine; Chiral Ferrocenylphosphine Ligand J009-1
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management protocols to ensure consistency and performance. We guarantee high chemical and chiral purity, verified by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with each shipment. Our quality systems support development and cGMP manufacturing requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity, this material should be stored under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Recommended long-term storage conditions are in a freezer at -20°C to -10°C. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.