Description

3-Demethyl Thiocolchicine 3-o-β-D-Glucuronide is a high-purity, semi-synthetic derivative of the colchicine alkaloid, modified with a glucuronide moiety to enhance its solubility and metabolic profile. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a reference standard or a key intermediate in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology, anti-inflammatory, and metabolic disease research.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (HPLC, LC-MS) of drug substances and metabolites in research and quality control laboratories.
• Metabolite Studies: Serves as a critical analytical standard for identifying and quantifying glucuronidated metabolites in pharmacokinetic and ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Medicinal Chemistry Intermediate: Acts as a key building block for the synthesis of novel colchicine analogs with potential improved efficacy and reduced toxicity profiles.
• Biochemical Research: Employed in studies investigating tubulin polymerization inhibition and its effects on cellular processes like mitosis and inflammation.
• Impurity Standard: Used to identify, monitor, and control related substances in the manufacturing of colchicine-derived active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3-Demethyl Thiocolchicine 3-o-β-D-Glucuronide
CAS No.	819802-34-1
Molecular Formula	C28H33NO12S
Molecular Weight	607.63 g/mol
Synonyms	Thiocolchicoside 3-O-β-D-Glucuronide; 3-Demethylthiocolchicine 3-Glucuronide; N-Deacetyl-N-methylthiocolchicine 3-Glucuronide; 3-O-(β-D-Glucopyranosyluronic acid)-3-demethylthiocolchicine; (7S)-3-(β-D-Glucopyranuronosyloxy)-1,2,3,10-tetramethoxy-9-(methylsulfanyl)-6,7-dihydro-5H-benzo[a]heptalen-7-ol
EINECS	Contact for details

Quality Control

Our 3-Demethyl Thiocolchicine 3-o-β-D-Glucuronide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, LC-MS for identity confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.