Description

4-Amino-2-Fluorophenylboronic Acid, Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry. Its core value lies in its stability and reactivity, serving as a crucial building block for constructing complex molecular architectures. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for applications like Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific fluorinated aromatic structures.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air- and moisture-tolerant boronate ester reagent for palladium-catalyzed carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the creation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Materials Science Research: Utilized in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic units are desirable.
• Chemical Biology Probes: Acts as a precursor for bioconjugation reagents and probes used in diagnostic and imaging applications.

Basic Information

Product Name	4-Amino-2-Fluorophenylboronic Acid, Pinacol Ester
CAS No.	819057-45-9
Molecular Formula	C12H17BFNO2
Molecular Weight	237.08 g/mol
Synonyms	2-Fluoro-4-aminophenylboronic acid pinacol ester; 4-Amino-2-fluorobenzeneboronic acid pinacol ester; (4-Amino-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-4-aminophenyl-Bpin; B-(4-Amino-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(4-amino-2-fluorophenyl)-1,3,2-dioxaborolane; 819057-45-9; 4-Amino-2-fluorophenylboronate pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Fluorophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. Certificates of Analysis (COA) detailing the specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.