Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, α-(2-Carboxyethyl)-, 1,4,7,10-Tetrakis(1,1-Dimethylethyl) Ester, (αr)- is a key protected intermediate in the synthesis of advanced macrocyclic chelating agents. This compound is critically important for the development of high-performance contrast agents used in magnetic resonance imaging (MRI) and other diagnostic applications. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and companies specializing in medical imaging technology for producing novel gadolinium-based and other lanthanide complexes.

Application

• Pharmaceutical Intermediate: A crucial protected precursor for synthesizing DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and DOTA-like bifunctional chelators.
• MRI Contrast Agent Development: Used in the research and production of next-generation gadolinium(III) and other lanthanide-based contrast agents for enhanced imaging diagnostics.
• Radiopharmaceuticals: Serves as a building block for chelators that bind radioisotopes (e.g., 68Ga, 177Lu, 90Y) for targeted cancer therapy and diagnostic imaging (PET/SPECT).
• Chemical Research: Employed in academic and industrial research to study macrocyclic chemistry, coordination complexes, and metal ion sequestration.
• Bioconjugation Linker: The protected ester groups allow for selective deprotection and conjugation to antibodies, peptides, or other targeting molecules.
• Catalyst Ligand Synthesis: A starting material for creating specialized ligands used in homogeneous catalysis and material science.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, α-(2-Carboxyethyl)-, 1,4,7,10-Tetrakis(1,1-Dimethylethyl) Ester, (αr)-
CAS No.	817562-90-6
Molecular Formula	C40H72N4O12
Molecular Weight	800.99 g/mol
Synonyms	(αR)-α-(2-Carboxyethyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid 1,4,7,10-tetrakis(1,1-dimethylethyl) ester; DOTA-tris(t-Bu ester) (αR isomer); DOTA-tris(t-butyl ester)-α-(2-carboxyethyl) (R); (R)-2-(4,7,10-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanedioic acid 1,5-di-tert-butyl ester; Protected DOTA-GA tris(t-butyl) ester (R); Bifunctional DOTA-tris(t-Bu ester) precursor; 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid, α-(2-carboxyethyl)-, 1,4,7,10-tetrakis(1,1-dimethylethyl) ester, (αR)-
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for research and scale-up processes. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, isomeric purity, and chemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications such as assay, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.