Description

6-Chloro-9-(2'-Deoxy-2'-Fluoro-2-C-Methyl-β-D-Ribofuranosyl)-9H-Purine is a high-purity nucleoside analog building block critical for advanced pharmaceutical research and development. This compound serves as a key synthetic intermediate in the production of antiviral and anticancer therapeutics, particularly in the development of modified nucleoside prodrugs. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality raw materials for API synthesis and novel drug discovery programs.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of antiviral and anticancer Active Pharmaceutical Ingredients (APIs).
• Antiviral Drug Development: Used in research and production of nucleoside analog drugs targeting viral polymerases.
• Oncology Research: Serves as a precursor in the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Prodrug Synthesis: Key starting material for creating modified nucleoside prodrugs with enhanced bioavailability and targeted delivery.
• Biochemical Research: Used in studies investigating enzyme mechanisms, particularly those involving nucleotide metabolism and polymerase inhibition.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for commercial drug manufacturing.

Basic Information

Product Name	6-Chloro-9-(2'-Deoxy-2'-Fluoro-2-C-Methyl-β-D-Ribofuranosyl)-9H-Purine
CAS No.	817204-42-5
Molecular Formula	C11H12ClFN4O3
Molecular Weight	302.69 g/mol
Synonyms	2'-Deoxy-2'-fluoro-2-C-methyl-6-chloropurine riboside; 6-Chloro-9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]purine; 2'-Fluoro-2-C-methyl-6-chloropurine nucleoside; 6-Chloro-7-deaza-2'-C-methyl-2'-fluoropurine riboside; 6-Chloro-2'-deoxy-2'-fluoro-2'-C-methylpurine ribonucleoside; PSI-6130 impurity; RO2433 related compound
EINECS	Contact for details

Quality Control

Our 6-Chloro-9-(2'-Deoxy-2'-Fluoro-2-C-Methyl-β-D-Ribofuranosyl)-9H-Purine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities to ensure compliance with pharmaceutical-grade standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.