Description

(3E)-1,1,1-Trifluoro-4-(4-Methylphenyl)-3-Buten-2-Imine is a specialized fluorinated imine building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for its ability to modulate biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of fluorinated polymers and advanced organic electronic materials for their unique electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and scale-up services for clients in life sciences.

Basic Information

Product Name	(3E)-1,1,1-Trifluoro-4-(4-Methylphenyl)-3-Buten-2-Imine
CAS No.	817164-07-1
Molecular Formula	C11H10F3N
Molecular Weight	213.20 g/mol
Synonyms	(E)-1,1,1-Trifluoro-4-(p-tolyl)but-3-en-2-imine; 1,1,1-Trifluoro-4-(4-methylphenyl)-3-buten-2-imine, (3E)-; 4-Methyl-α-[(trifluoromethyl)imino]styrene; (E)-4-Methyl-α-[(trifluoromethyl)imino]styrene; p-Tolyl α-trifluoromethyl ketimine; (E)-1,1,1-Trifluoro-4-(4-methylphenyl)-3-buten-2-imine
EINECS	Contact for details

Quality Control

Our (3E)-1,1,1-Trifluoro-4-(4-Methylphenyl)-3-Buten-2-Imine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z Ratio)	≥ 98:2 (E:Z)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.