Description

Benzonitrile, 3-[[(2R,3R)-2-Methyl-4-Oxo-3-Azetidinyl]Methyl]- (9Ci) is a high-purity, advanced pharmaceutical intermediate featuring a benzonitrile moiety linked to a functionalized azetidinone ring. This compound matters for its critical role as a key building block in the synthesis of novel β-lactam antibiotics and other biologically active molecules. Pharmaceutical R&D teams and fine chemical manufacturers need this precise chiral intermediate to develop next-generation therapeutic agents targeting resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the research and production of novel β-lactam antibiotics.
• Antibiotic Development: Used in the synthesis of advanced cephalosporin and penicillin analogs with improved efficacy.
• Medicinal Chemistry Research: A valuable building block for constructing complex molecular libraries in drug discovery programs.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating specialized, high-value chemical entities.
• Bioconjugate Chemistry: Potential use in linking pharmacophores due to its reactive nitrile and ketone functionalities.

Basic Information

Product Name	Benzonitrile, 3-[[(2R,3R)-2-Methyl-4-Oxo-3-Azetidinyl]Methyl]- (9Ci)
CAS No.	815578-28-0
Molecular Formula	C12H12N2O
Molecular Weight	200.24 g/mol
Synonyms	3-[(2R,3R)-2-Methyl-4-oxo-3-azetidinyl]methyl]benzonitrile; (2R,3R)-3-[(3-Cyanophenyl)methyl]-2-methylazetidin-4-one; 3-((2R,3R)-2-Methyl-4-oxo-3-azetidinyl)methylbenzonitrile; Azetidinone benzonitrile derivative; β-lactam intermediate 815578-28-0; Chiral azetidinone nitrile; Pharmaceutical intermediate CAS 815578-28-0
EINECS	Contact for details

Quality Control

Our Benzonitrile, 3-[[(2R,3R)-2-Methyl-4-Oxo-3-Azetidinyl]Methyl]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.