Description

Palonosetron n-Oxide is a key pharmaceutical intermediate and metabolite of the antiemetic drug Palonosetron. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on developing and improving next-generation anti-nausea and chemotherapy-induced nausea and vomiting (CINV) treatments.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and scale-up production of Palonosetron and its derivative compounds.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify Palonosetron metabolites in biological samples.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Essential for investigating the metabolic pathways, bioavailability, and clearance mechanisms of Palonosetron.
• Impurity Profiling: Serves as a known impurity or degradation product standard for quality control and stability testing of Palonosetron API batches.
• Process Development: Used in the optimization of synthetic routes and purification processes for Palonosetron manufacturing.
• Academic and Clinical Research: Supports fundamental research into serotonin 5-HT3 receptor antagonists and their mechanisms of action.

Basic Information

Product Name	Palonosetron n-Oxide
CAS No.	813425-83-1
Molecular Formula	C19H24N2O2
Molecular Weight	312.41 g/mol
Synonyms	(3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one N-Oxide; Palonosetron Impurity F (N-Oxide); Palonosetron Related Compound F; Palonosetron N-Oxide; (3aS)-2-[(3S)-1-Oxido-1-azoniabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
EINECS	Contact for details

Quality Control

Our Palonosetron n-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.