Description

4-Amino-1-n-Fmoc-Piperidine Hydrochloride is a high-purity, protected piperidine derivative essential for advanced organic synthesis. This compound serves as a critical building block in the development of complex molecules, offering a reactive amine group shielded by the base-labile Fmoc protecting group. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide synthesis, medicinal chemistry, and the creation of novel chemical libraries.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for introducing the 4-aminopiperidine moiety into peptide sequences under standard Fmoc deprotection conditions.
• Medicinal Chemistry & Drug Discovery: Used as a versatile scaffold and building block for constructing pharmacologically active compounds, particularly in targeting GPCRs and kinases.
• Combinatorial Chemistry: Employed in the generation of diverse compound libraries for high-throughput screening to identify new lead molecules.
• Chemical Biology Probes: Facilitates the synthesis of labeled or tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis Services: A fundamental starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals and APIs.

Basic Information

Product Name	4-Amino-1-n-Fmoc-Piperidine Hydrochloride
CAS No.	811841-89-1
Molecular Formula	C₂₁H₂₅N₂O₂•HCl
Molecular Weight	380.90 g/mol
Synonyms	1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-aminopiperidine hydrochloride; 4-Amino-1-Fmoc-piperidine HCl; 1-N-Fmoc-4-aminopiperidine hydrochloride; Fmoc-4-Amino-piperidine HCl; N-α-Fmoc-4-aminopiperidine hydrochloride; 4-Amino-1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperidine hydrochloride; Piperidine, 4-amino-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 4-Amino-1-n-Fmoc-Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.