Description

1,2-Difluoro-3,4,5-Tribromobenzene is a high-purity, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both fluorine and bromine substituents, makes it a valuable precursor for creating complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as catalyst ligand synthesis and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, particularly those requiring halogenated aromatic cores for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the difluoro-tribromo motif can influence binding and environmental persistence.
• Material Science Precursor: Acts as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Catalyst & Ligand Development: Employed to synthesize novel phosphine or N-heterocyclic carbene (NHC) ligands for transition metal catalysis, leveraging the steric bulk of the bromine atoms.
• Chemical Research: A versatile substrate for cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution, enabling rapid diversification in medicinal chemistry libraries.

Basic Information

Product Name	1,2-Difluoro-3,4,5-Tribromobenzene
CAS No.	811713-80-1
Molecular Formula	C6HBr3F2
Molecular Weight	370.78 g/mol
Synonyms	1,2-Difluoro-3,4,5-tribromobenzene; 3,4,5-Tribromo-1,2-difluorobenzene; Benzene, 1,2-difluoro-3,4,5-tribromo-; 1,2-Difluoro-3,4,5-tribromo-benzene; Tribromodifluorobenzene (mixed isomer reference); DFTBB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1,2-Difluoro-3,4,5-Tribromobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.