Description

Boc-Dl-Cyclobutylglycine is a protected amino acid derivative featuring a cyclobutyl side chain and a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, enabling advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and process chemistry applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides and small molecule drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the cyclobutylglycine moiety into peptide chains.
• Protease Inhibitor Development: Serves as a building block for creating inhibitors targeting specific proteolytic enzymes.
• Structure-Activity Relationship (SAR) Studies: Employed to explore the impact of the constrained cyclobutyl ring on peptide conformation and biological activity.
• Bioconjugation & Labeling: The Boc-protected amino acid can be used in the preparation of modified peptides for diagnostic or targeting applications.
• Academic & Industrial R&D: A valuable reagent for chemical biology research and the development of new synthetic methodologies.

Basic Information

Item	Detail
Product Name	Boc-Dl-Cyclobutylglycine
CAS No.	811460-95-4
Molecular Formula	C₁₁H₁₉NO₄
Molecular Weight	229.27 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-DL-cyclobutylglycine; (RS)-2-[(tert-Butoxycarbonyl)amino]-2-cyclobutylacetic Acid; Boc-Cbg-OH; Boc-DL-2-Amino-2-cyclobutylacetic Acid; DL-2-((tert-Butoxycarbonyl)amino)-2-cyclobutylacetic Acid; N-Boc-DL-cyclobutylglycine; Cyclobutylglycine, N-Boc-DL-; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclobutylacetic Acid
EINECS	Contact for details

Quality Control

Our Boc-Dl-Cyclobutylglycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.