Description

Cyclopropanecarboxylic Acid, 2-Fluoro-2-(4-Methylphenyl)-, Ethyl Ester, (1R,2R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its core value lies in its unique cyclopropane ring fused with a fluorinated aromatic system, providing a rigid, three-dimensional scaffold that is crucial for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and process development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorinated cyclopropane moiety can enhance metabolic stability and binding affinity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of the fluorinated cyclopropane structure on potency and selectivity.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of complex molecules.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory filings in drug development pipelines.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Fluoro-2-(4-Methylphenyl)-, Ethyl Ester, (1R,2R)-Rel- (9Ci)
CAS No.	809282-90-4
Molecular Formula	C13H15FO2
Molecular Weight	222.26 g/mol
Synonyms	(1R,2R)-rel-2-Fluoro-2-(4-methylphenyl)cyclopropanecarboxylic acid ethyl ester; Ethyl (1R,2R)-rel-2-fluoro-2-(p-tolyl)cyclopropanecarboxylate; rel-(1R,2R)-2-Fluoro-2-(4-methylphenyl)cyclopropanecarboxylic Acid Ethyl Ester; Fluorinated Chiral Cyclopropane Ester; 2-Fluoro-2-(4-methylphenyl)cyclopropanecarboxylic acid ethyl ester, (1R,2R)-rel-
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Fluoro-2-(4-Methylphenyl)-, Ethyl Ester, (1R,2R)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (1R,2R)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.