Description

(2,3-Difluorophenyl)Acetyl Chloride is a high-purity, reactive organofluorine building block essential for advanced chemical synthesis. This compound serves as a critical acylating agent for introducing the (2,3-difluorophenyl)acetyl moiety into target molecules, enabling precise structural modifications. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluorophenyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers and functional polymers with specific electronic or surface properties.
• Custom Chemical Synthesis: A versatile reagent for contract research organizations (CROs) and CDMOs producing bespoke fluorinated compounds for client projects.

Basic Information

Product Name	(2,3-Difluorophenyl)Acetyl Chloride
CAS No.	808144-32-3
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	2,3-Difluorophenylacetyl Chloride; 2-(2,3-Difluorophenyl)acetyl Chloride; (2,3-Difluorophenyl)acetic Acid Chloride; α-Chloro-2,3-difluoroacetophenone; 2,3-DFPACl; 808144-32-3; 2-(2,3-Difluorophenyl)-2-oxoethyl Chloride
EINECS	Contact for details

Quality Control

Every batch of (2,3-Difluorophenyl)Acetyl Chloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.