Description

Difluoro-(4-Fluoro-Phenoxy)-Acetic Acid Ethyl Ester is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, where its specific fluorine substitution pattern enables precise modulation of biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and pesticides, where fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance and surface properties.
• Organic Electronics: Acts as a synthon for materials used in organic light-emitting diodes (OLEDs) and semiconductor layers.
• Chemical Research: A valuable reagent for method development in fluorination chemistry and cross-coupling reactions.

Basic Information

Product Name	Difluoro-(4-Fluoro-Phenoxy)-Acetic Acid Ethyl Ester
CAS No.	807368-70-3
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	Ethyl 2,2-difluoro-2-(4-fluorophenoxy)acetate; Ethyl Difluoro(4-fluorophenoxy)acetate; 2,2-Difluoro-2-(4-fluorophenoxy)acetic Acid Ethyl Ester; Acetic acid, 2,2-difluoro-2-(4-fluorophenoxy)-, ethyl ester; 807368-70-3; Ethyl α,α-difluoro-α-(p-fluorophenoxy)acetate; 4-Fluorophenoxy(difluoro)acetic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Difluoro-(4-Fluoro-Phenoxy)-Acetic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and industrial intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.