Description

(1R,2S)-Ethyl 2-(tert-Butoxycarbonylamino)Cyclohexanecarboxylate is a high-purity, chiral building block of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, which is critical for biological activity. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapeutics.
• Peptidomimetic Chemistry: Used to introduce constrained cyclohexyl-based amino acid analogs into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands and organocatalysts.
• Agrochemical Synthesis: Employed in the research and production of enantiomerically pure pesticides and herbicides.
• Academic & Industrial Research: A valuable reagent for methodological development in stereoselective synthesis and medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP or non-GMP conditions.

Basic Information

Item	Details
Product Name	(1R,2S)-Ethyl 2-(tert-Butoxycarbonylamino)Cyclohexanecarboxylate
CAS No.	805994-98-3
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	(1R,2S)-Ethyl 2-((tert-Butoxycarbonyl)amino)cyclohexanecarboxylate; (1R,2S)-N-Boc-2-Carbethoxycyclohexylamine; trans-N-Boc-2-Ethoxycarbonylcyclohexylamine; Ethyl (1R,2S)-2-[(tert-butoxycarbonyl)amino]cyclohexane-1-carboxylate; Boc-(1R,2S)-ACHC-OEt; (1R,2S)-2-(Boc-amino)cyclohexanecarboxylic acid ethyl ester; Ethyl trans-2-(N-Boc-amino)cyclohexanecarboxylate
EINECS	Contact for details

Quality Control

Our (1R,2S)-Ethyl 2-(tert-Butoxycarbonylamino)Cyclohexanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (nitrogen) after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.