Description

Cyclohexanecarbonitrile, 2-Ethyl-1-[(trimethylsilyl)oxy]-, (1R,2R)-rel- (9CI) is a high-purity, chiral synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for constructing complex, stereochemically defined molecules, particularly in the pharmaceutical sector. This compound is primarily needed by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or infectious diseases.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and insecticides where specific stereochemistry enhances efficacy and reduces environmental impact.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Material Science: Potential application in the synthesis of chiral liquid crystals or advanced polymers with specific optical properties.
• Academic & Process Chemistry: Employed in university and industrial R&D labs for methodological studies in stereoselective synthesis and scale-up process optimization.

Basic Information

Item	Detail
Product Name	Cyclohexanecarbonitrile, 2-Ethyl-1-[(trimethylsilyl)oxy]-, (1R,2R)-rel- (9CI)
CAS No.	804563-35-7
Molecular Formula	C12H23NOSi
Molecular Weight	225.41 g/mol
Synonyms	rel-(1R,2R)-2-Ethyl-1-[(trimethylsilyl)oxy]cyclohexanecarbonitrile; (1R,2R)-rel-2-Ethyl-1-(trimethylsilyloxy)cyclohexanecarbonitrile; 2-Ethyl-1-(trimethylsilyloxy)cyclohexanecarbonitrile (rel-(1R,2R)-); 1-[(Trimethylsilyl)oxy]-2-ethylcyclohexanecarbonitrile (rel-(1R,2R)-); TMS-protected 2-ethyl-1-hydroxycyclohexanecarbonitrile; Cyclohexanecarbonitrile, 1-[(trimethylsilyl)oxy]-2-ethyl-, rel-(1R,2R)-
EINECS	Contact for details

Quality Control

Our production of Cyclohexanecarbonitrile, 2-Ethyl-1-[(trimethylsilyl)oxy]-, (1R,2R)-rel- (9CI) adheres to stringent quality protocols suitable for research and cGMP starting material applications. Every batch undergoes rigorous analytical testing to ensure high chiral purity and chemical identity. Comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (rel-(1R,2R)-)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.