Description

Bis(Pyrrolidino)Methoxyphosphine is a specialized organophosphorus compound that serves as a versatile reagent in advanced chemical synthesis. Its primary value lies in its role as a phosphitylating agent, crucial for constructing complex molecular architectures. This product is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of nucleoside analogs and oligonucleotide precursors.

Application

• Phosphoramidite Synthesis: A key reagent for the preparation of nucleoside phosphoramidites, the building blocks for oligonucleotide (DNA/RNA) synthesis.
• Pharmaceutical Intermediates: Used in the synthesis of antiviral and anticancer prodrugs, especially those containing phosphate or phosphonate groups.
• Agrochemical Production: Employed in creating novel pesticides and herbicides with specific modes of action.
• Ligand and Catalyst Preparation: Acts as a precursor for chiral phosphorus-containing ligands used in asymmetric catalysis.
• Material Science Research: Utilized in the development of novel polymers and flame retardants with tailored properties.
• Process Chemistry: Applied in scalable manufacturing routes for active pharmaceutical ingredients (APIs) requiring phosphorus incorporation.

Basic Information

Product Name	Bis(Pyrrolidino)Methoxyphosphine
CAS No.	89983-14-2
Molecular Formula	C9H19N2OP
Molecular Weight	202.24 g/mol
Synonyms	Methoxybis(pyrrolidino)phosphine; (Methoxy)bis(1-pyrrolidinyl)phosphine; Phosphinous amide, methoxybis(pyrrolidino)-; Bis(1-pyrrolidinyl)methoxyphosphine; Methoxybis(pyrrolidino)phosphine; P-Methoxy-N,N'-dipyrrolidinylphosphinous amide
EINECS	Contact for details

Quality Control

Our Bis(Pyrrolidino)Methoxyphosphine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical-grade intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation and moisture, the container should be flushed with inert gas after each opening. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.