Description

n-Hydroxy-n-Glucuronosyl-2-Aminofluorene is a specific glucuronide conjugate of a hydroxylated aminofluorene derivative, representing a key metabolite in the study of aromatic amine metabolism. This compound is of significant value in biochemical and toxicological research for investigating metabolic activation, detoxification pathways, and DNA adduct formation. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and contract research organizations (CROs) focused on carcinogenesis, drug metabolism, and pharmacokinetic studies.

Application

• Biochemical Research Standard: Used as a high-purity reference standard for the qualitative and quantitative analysis of metabolic pathways involving aromatic amines.
• Toxicology Studies: Critical for investigating the metabolic fate, bioactivation, and detoxification mechanisms of aminofluorene derivatives and related procarcinogens.
• DNA Adduct Research: Employed in studies to understand the formation and repair of specific DNA adducts, which is fundamental to carcinogenicity research.
• Pharmacokinetic & Metabolism (DMPK): Serves as a metabolite marker in in vitro and in vivo studies to elucidate the Phase II conjugation (glucuronidation) profile of parent compounds.
• Analytical Method Development: Utilized as a calibrant or internal standard in the development and validation of LC-MS/MS, HPLC, and other chromatographic assays.

Basic Information

Product Name	n-Hydroxy-n-Glucuronosyl-2-Aminofluorene
CAS No.	89947-76-2
Molecular Formula	C₂₀H₂₀N₂O₈
Molecular Weight	416.38 g/mol
Synonyms	N-Hydroxy-N-glucuronosyl-2-aminofluorene; 2-Aminofluorene N-glucuronide; N-(Glucuronosyloxy)-2-aminofluorene; AF-Gluc; Aminofluorene glucuronide metabolite; N-Hydroxy-2-aminofluorene glucuronide; N-Glucuronosyloxy-2-fluorenamine
EINECS	Contact for details

Quality Control

Our n-Hydroxy-n-Glucuronosyl-2-Aminofluorene is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.