Description

4'-Deoxydoxorubicinol is a key intermediate and reference standard in the synthesis and analytical profiling of anthracycline-based pharmaceuticals. This compound is of critical importance for research and development in oncology, enabling the study of drug metabolism, impurity profiling, and the development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) and high-purity fine chemicals.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of related substances in doxorubicin and other anthracycline drug products.
• Metabolite Research: Serves as a critical metabolite standard for pharmacokinetic and pharmacodynamic studies of anthracycline chemotherapeutics.
• Process Chemistry & Impurity Control: Employed as an intermediate and impurity marker in the synthesis and quality control of complex anticancer APIs.
• Analytical Method Development: Essential for developing and validating HPLC, LC-MS, and other chromatographic methods in pharmaceutical analysis.
• Biochemical Research: Used in studies investigating the mechanisms of action, cardiotoxicity, and resistance pathways of anthracycline drugs.

Basic Information

Product Name	4'-Deoxydoxorubicinol
CAS No.	89780-72-3
Molecular Formula	C27H29NO10
Molecular Weight	527.52 g/mol
Synonyms	4'-Deoxy-13-dihydrodoxorubicin; 4'-Deoxy-13-dihydrodoxorubicinol; 7-Deoxy-13-dihydrodoxorubicin aglycone; Doxorubicinol, 4'-deoxy-; (7S,9S)-7-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl)oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
EINECS	Contact for details

Quality Control

Our 4'-Deoxydoxorubicinol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the stringent requirements for pharmaceutical research and reference standards. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.