Description

7,8-Dihydroxy-7,8-Dihydro-8-Methylbenzo(A)Pyrene CAS NO 89524-80-1 is a high-purity, advanced intermediate and reference standard derived from the polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene. This compound is of significant value in toxicological and environmental research due to its role as a key metabolite in the bioactivation pathway of benzo(a)pyrene, a well-known carcinogen. It is primarily required by research institutions, analytical laboratories, and pharmaceutical companies engaged in metabolic studies, biomarker analysis, and the development of detection methods for PAH exposure and DNA adduct formation.

Application

• Toxicological Research: Used as a critical metabolite standard to study the metabolic activation, detoxification pathways, and carcinogenic mechanisms of benzo(a)pyrene.
• Environmental Analysis: Serves as a high-purity reference material for the calibration of analytical equipment (HPLC, GC-MS) in monitoring PAH pollution and human exposure biomarkers in environmental and biological samples.
• Biomarker Development: Essential for the synthesis and quantification of DNA and protein adducts, facilitating research into molecular epidemiology and cancer risk assessment.
• Pharmaceutical R&D: Employed in early-stage drug discovery programs focused on designing chemopreventive agents or inhibitors that target specific metabolic enzymes like cytochrome P450.
• Academic Research: A key reagent for universities and research institutes conducting fundamental studies in organic chemistry, biochemistry, and molecular toxicology related to PAHs.
• Quality Control & Method Validation: Used by testing laboratories to validate and ensure the accuracy of analytical methods for PAH metabolite detection in compliance with regulatory guidelines.

Basic Information

Product Name	7,8-Dihydroxy-7,8-Dihydro-8-Methylbenzo(A)Pyrene
CAS No.	89524-80-1
Molecular Formula	C21H16O2
Molecular Weight	300.35 g/mol
Synonyms	8-Methylbenzo[a]pyrene-7,8-dihydrodiol; 7,8-Dihydro-7,8-dihydroxy-8-methylbenzo[a]pyrene; 8-Methyl-BP-7,8-diol; 8-Methyl-B[a]P-7,8-dihydrodiol; trans-7,8-Dihydroxy-7,8-dihydro-8-methylbenzo[a]pyrene; 8-Methylbenzopyrene Dihydrodiol; BP-7,8-diol-8-methyl; A metabolite of 8-Methylbenzo[a]pyrene
EINECS	Contact for details

Quality Control

Our 7,8-Dihydroxy-7,8-Dihydro-8-Methylbenzo(A)Pyrene is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, which is critical for sensitive research applications. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) providing full specification data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and ensure long-term stability. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.