Description

L-Alanine (U-13C3) is a stable isotope-labeled amino acid where all three carbon atoms are uniformly enriched with the 13C isotope. This high-purity compound is essential for advanced research requiring precise metabolic and structural analysis. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications such as metabolic pathway tracing, protein NMR spectroscopy, and the development of isotopically labeled biomarkers and therapeutics.

Application

• Metabolic Flux Analysis (MFA): Used as a 13C-labeled tracer to study central carbon metabolism and quantify intracellular reaction rates in biological systems.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Serves as a critical tool for protein structure determination and dynamic studies, providing unambiguous signal assignments.
• Mass Spectrometry (MS) Standards: Acts as an internal standard for the accurate quantification of alanine and related metabolites in complex biological samples via LC-MS or GC-MS.
• Drug Discovery & Development: Employed in the research and production of isotopically labeled active pharmaceutical ingredients (APIs) for pharmacokinetic and pharmacodynamic studies.
• Nutritional Research: Utilized in studies investigating amino acid metabolism, protein synthesis, and turnover in humans and animals.
• Diagnostic Agent Development: A key precursor in the synthesis of 13C-labeled diagnostic probes for breath tests and medical imaging.

Basic Information

Product Name	L-Alanine (U-13C3)
CAS No.	100108-77-8
Molecular Formula	¹³C₃H₇NO₂
Molecular Weight	92.05 g/mol (for ¹³C₃ isotopologue)
Synonyms	(2S)-2-Aminopropanoic acid-¹³C₃; L-α-Alanine-¹³C₃; (S)-Alanine-¹³C₃; Alanine-13C3; U-13C3-L-Alanine; Uniformly 13C-labeled L-Alanine; 13C3-L-Ala; NSC 7604-¹³C₃
EINECS	Contact for details

Quality Control

Our L-Alanine (U-13C3) is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % 13C), chemical purity, chiral purity, and residual solvent content. We adhere to cGMP principles for production and can support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to prevent moisture uptake. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Specific Rotation	+13.5° to +15.5° (c=5 in 5N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.