Description

4-Hydroxy Nonenal-Dimethylacetal is a protected derivative of 4-hydroxy-2-nonenal (4-HNE), a key bioactive lipid peroxidation product. This dimethylacetal form offers enhanced stability, making it a crucial analytical standard and research chemical for studying oxidative stress and related biological pathways. It is essential for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and life science sectors who require high-purity reference materials for method development and validation.

Application

• Biomarker Research: Serves as a stable standard for the quantification of 4-HNE, a primary marker of lipid peroxidation and oxidative stress in biological systems.
• Pharmaceutical R&D: Used in the study of cellular signaling pathways, inflammation, apoptosis, and the development of diseases related to oxidative damage, such as neurodegenerative disorders and atherosclerosis.
• Analytical Method Development: Critical for developing and validating sensitive analytical methods (e.g., GC-MS, LC-MS/MS) for the detection of lipid-derived aldehydes in complex matrices.
• Reference Standard Production: Employed by manufacturers of diagnostic kits and calibration standards for clinical and research laboratories.
• Food & Nutraceutical Science: Applied in research on lipid oxidation in foods and the efficacy of antioxidants.
• Toxicology Studies: Utilized to investigate the mechanisms of cytotoxicity and genotoxicity induced by reactive carbonyl species.

Basic Information

Product Name	4-Hydroxy Nonenal-Dimethylacetal
CAS No.	119009-01-7
Molecular Formula	C₁₁H₂₂O₃
Molecular Weight	202.29 g/mol
Synonyms	4-HNE-Dimethylacetal; 4-Hydroxy-2-nonenal Dimethyl Acetal; (E)-4-Hydroxynon-2-enal Dimethyl Acetal; 4-Hydroxy-2-nonenal 1,1-Dimethyl Acetal; 4-HNE DMA; 4-HNE-DMA; 4-Hydroxynonenal Dimethylacetal; Non-2-en-1-al, 4-hydroxy-, dimethyl acetal
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Nonenal-Dimethylacetal is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity assessment (HPLC/GC) and structural confirmation (NMR, MS), to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed batch-specific results are provided and available upon request to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.