Description

Creatine-14C is a radiolabeled isotopologue of creatine, a vital nitrogenous organic acid, where a carbon-14 atom is incorporated into its molecular structure. This specific labeling makes it an indispensable tool for metabolic pathway tracing and pharmacokinetic studies in research and development. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced biochemical and pharmacological research.

Application

• Metabolic Tracer Studies: Used to investigate the biosynthesis, distribution, and catabolism of creatine and phosphocreatine in muscular and neurological tissues.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for tracking the absorption, distribution, metabolism, and excretion (ADME) of novel creatine-based therapeutics or supplements.
• Biochemical Pathway Analysis: Enables precise elucidation of the creatine kinase/phosphocreatine system's role in cellular energy buffering and transport.
• Nutritional Research: Applied in studies examining the bioavailability, uptake mechanisms, and efficacy of dietary creatine supplements in sports science.
• Diagnostic Agent Development: Serves as a precursor in the research and development of potential diagnostic imaging agents.
• Quality Control Reference Standard: Can be employed as an internal standard in analytical methods (e.g., LC-MS) for the quantification of creatine in complex matrices.

Basic Information

Product Name	Creatine-14C
CAS No.	100482-07-3
Molecular Formula	C4H914CN3O2
Molecular Weight	~ 134.13 g/mol (for unlabeled); specific activity provided on CoA
Synonyms	N-Amidinosarcosine-14C; (α-Methylguanidino)acetic acid-14C; N-Carbamimidoyl-N-methylglycine-14C; 1-Carboxymethyl-2-iminoimidazolidine-14C; Creatine (carbon-14 labeled); [14C]Creatine; Radiolabeled Creatine
EINECS	Contact for details

Quality Control

Every batch of Creatine-14C is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Comprehensive testing includes radiochemical purity (RCP) determination by HPLC, specific activity measurement, and confirmation of chemical identity. A detailed Certificate of Analysis (CoA), which includes chromatographic data and analytical results, is supplied with each shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere if specified and stored in a dry environment. For long-term stability, storage at -20°C is recommended. Please refer to the specific CoA and Material Safety Data Sheet (MSDS) for detailed handling and storage instructions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Customized; mCi/mmol range (provided on CoA)
Solvent (if supplied as solution)	Specified on CoA (e.g., Ethanol, Water)
Radioactive Concentration	Provided on CoA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.