Description

Cisplatin-Deoxy(Adenosine Monophosphate Guanosine) Adduct is a well-characterized, site-specific DNA adduct formed by the reaction of the anticancer drug cisplatin with a d(GpG) sequence in DNA. This compound is of significant value as a critical reference standard and research tool in the fields of bioanalytical chemistry and molecular toxicology. It is primarily utilized by research scientists and quality control laboratories in pharmaceutical development, academic institutions, and contract research organizations (CROs) to study platinum-DNA interactions, validate analytical methods, and investigate mechanisms of drug efficacy and resistance.

Application

• Biomarker and Metabolite Research: Serves as a definitive standard for identifying and quantifying cisplatin-DNA adducts in biological samples, crucial for pharmacokinetic and pharmacodynamic studies.
• Analytical Method Development & Validation: Used as a certified reference material (CRM) to calibrate and validate sensitive detection techniques like LC-MS/MS, HPLC-UV, and atomic absorption spectroscopy.
• Mechanistic Toxicology Studies: Enables detailed investigation into the molecular mechanisms of cisplatin-induced cytotoxicity, DNA damage recognition, and repair pathways.
• Drug Discovery & Development: Acts as a key reagent in screening assays to evaluate the DNA-binding properties and mechanisms of novel platinum-based and non-platinum chemotherapeutic agents.
• Quality Control in Pharmaceutical Manufacturing: Employed as a system suitability standard in the QC testing of cisplatin API and related drug products to ensure batch consistency.
• Structural Biology Research: Provides a well-defined substrate for X-ray crystallography and NMR studies to elucidate the three-dimensional structure of platinated DNA.

Basic Information

Product Name	Cisplatin-Deoxy(Adenosine Monophosphate Guanosine) Adduct
CAS No.	119637-81-9
Molecular Formula	C20H28N10O12P2Pt
Molecular Weight	897.56 g/mol
Synonyms	cis-[Pt(NH3)2{d(GpG)-N7(1),-N7(2)}]; Cisplatin-d(GpG) Adduct; GG-Platinated Adduct; cis-Diammineplatinum(II)-d(GpG) Crosslink; Platinum-DNA Adduct (d(GpG)); 1,2-cis-{Pt(NH3)2}2+-d(GpG) Intrastrand Crosslink; Cisplatin-GG Adduct
EINECS	Contact for details

Quality Control

Every batch of our Cisplatin-Deoxy(Adenosine Monophosphate Guanosine) Adduct is produced and analyzed under strict quality protocols to ensure the highest standard of purity and structural integrity, suitable for demanding research applications. Comprehensive characterization is performed using advanced analytical techniques including NMR (1H, 195Pt), HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformity to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.