Description

3'-Azido-3'-Deoxythymidine-2-14C is a carbon-14 radiolabeled analog of the nucleoside reverse transcriptase inhibitor, AZT (Zidovudine). This isotopically labeled compound is an essential tool for conducting detailed pharmacokinetic, metabolic, and drug distribution studies in pharmaceutical research and development. It is primarily utilized by scientists and researchers in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise tracking of the parent drug molecule in biological systems.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) pathways of AZT in preclinical models.
• Metabolite Identification and Profiling: Using mass spectrometry to identify and characterize novel metabolites formed from the parent drug.
• Autoradiography and Whole-Body Imaging: Visualizing the tissue-specific distribution and accumulation of the drug compound.
• Environmental Fate Studies: Investigating the degradation and environmental persistence of pharmaceutical compounds in specialized research settings.
• Biochemical Pathway Analysis: Elucidating the specific enzymatic pathways involved in the activation or inactivation of nucleoside analogs.
• Reference Standard for Analytical Method Development: Serving as an internal standard in LC-MS/MS and other sensitive analytical techniques for quantitative bioanalysis.

Basic Information

Product Name	3'-Azido-3'-Deoxythymidine-2-14C
CAS No.	118896-97-2
Molecular Formula	C10H13N5O5 (with 14C at the 2-position)
Molecular Weight	~267.2 g/mol (exact mass depends on isotopic enrichment)
Synonyms	AZT-2-14C; Zidovudine-2-14C; 3'-Azido-2',3'-dideoxythymidine-2-14C; 1-[(2R,4S,5S)-4-Azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2-14C-pyrimidine-2,4-dione; BW A509U-2-14C; Azidothymidine-2-14C; Compound S-2-14C; Retrovir-2-14C (labeled)
EINECS	Contact for details

Quality Control

Every batch of 3'-Azido-3'-Deoxythymidine-2-14C is produced and analyzed under strict quality protocols to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on radiochemical purity, chemical purity, specific activity, and solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC & MS)	Conforms to reference standard
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.