Description

S-Cefotetan is a semi-synthetic, broad-spectrum cephamycin antibiotic derived from cephamycin C. This compound is valued for its potent activity against a wide range of Gram-negative and anaerobic bacteria, including β-lactamase-producing strains. It is a critical intermediate and active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the production of injectable antibiotic formulations.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of cefotetan disodium for injection, a second-generation cephalosporin antibiotic.
• Antibiotic Synthesis: Serves as a key chiral intermediate in the synthetic pathway for various cephamycin-based antibiotics.
• Research & Development: Used in microbiological and pharmacological research to study antibiotic efficacy, resistance mechanisms, and new combination therapies.
• Reference Standard: Employed as a high-purity chemical reference standard in quality control laboratories for HPLC, LC-MS, or NMR analysis.
• Veterinary Medicine: Potential application in developing antibacterial treatments for veterinary use.

Basic Information

Product Name	S-Cefotetan
CAS No.	89495-46-5
Molecular Formula	C₁₇H₁₇N₇O₈S₄
Molecular Weight	575.62 g/mol
Synonyms	(6R,7S)-7-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefotetan Intermediate; S(-)-Cefotetan; (6R,7S)-7-Methoxy-3-[(1-methyl-1H-tetrazol-5-ylthio)methyl]-8-oxo-7-[(2-(4-ethyl-2,3-dioxopiperazin-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our S-Cefotetan CAS NO 89495-46-5 is manufactured under cGMP conditions, ensuring the highest standards of purity and consistency for pharmaceutical applications. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as per in-house pharmacopeial standards. We commit to rigorous quality testing including chiral purity verification to guarantee the specified stereochemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a dry environment to prevent moisture absorption, which can affect stability and potency. Long-term storage under inert atmosphere (e.g., nitrogen) is recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (S-Isomer)	≥ 99.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Microbial Enumeration	Meets Ph. Eur. 2.6.12 criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.