Description

Helodermin is a bioactive peptide originally isolated from the venom of the Gila monster (*Heloderma suspectum*). This compound is of significant interest in biochemical and pharmacological research due to its potent biological activity as a vasoactive intestinal peptide (VIP) receptor agonist. It serves as a critical research tool for scientists and pharmaceutical developers investigating metabolic pathways, receptor signaling, and potential therapeutic applications in areas such as endocrinology and neurology.

Application

• Biomedical Research: Used as a high-purity reference standard and active agent in studies involving VIP receptor pharmacology and signal transduction mechanisms.
• Drug Discovery: Serves as a lead compound or molecular probe for developing novel therapeutics targeting metabolic disorders, inflammatory conditions, and neurological diseases.
• In Vitro Diagnostics: Employed in the development and calibration of immunoassays and other diagnostic tests designed to detect or quantify related biological pathways.
• Academic & Institutional Studies: Essential for university and institutional research projects focused on peptide biology, endocrinology, and comparative venom biochemistry.
• Biochemical Reagent: Acts as a key reagent in enzymatic studies, cell culture experiments, and receptor binding assays to elucidate complex biological functions.

Basic Information

Product Name	Helodermin
CAS No.	89468-62-2
Molecular Formula	C140H226N42O43
Molecular Weight	3085.6 g/mol
Synonyms	Helodermin (porcine); VIP Helodermin; HDM; Gila Monster Venom Peptide; Vasoactive Intestinal Peptide Helodermin; [Tyr10]-Helodermin; Helospectin I fragment; Peptide H.
EINECS	Contact for details

Quality Control

Our Helodermin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for research-grade biochemicals to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.