Description

3-Oxo-3-(2-Trifluoromethylphenyl)Propionic Acid Ethyl Ester is a high-value fluorinated organic intermediate with a versatile β-keto ester structure. This compound is critical for synthesizing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the trifluoromethyl group imparts desirable metabolic stability and lipophilicity. It is primarily sought by R&D chemists and process development teams for constructing heterocyclic scaffolds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the trifluoromethyl group for enhanced biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and coatings with unique chemical resistance.
• Organic Synthesis Reagent: Employed in Claisen condensation and Michael addition reactions to construct complex carbon skeletons in fine chemical manufacturing.
• Ligand and Catalyst Development: Utilized in the research and preparation of novel chelating ligands for catalytic systems in asymmetric synthesis.
• Fluorine Chemistry Research: An essential compound for academic and industrial research exploring the effects of fluorine substitution on molecular properties and reactivity.

Basic Information

Product Name	3-Oxo-3-(2-Trifluoromethylphenyl)Propionic Acid Ethyl Ester
CAS No.	89424-17-9
Molecular Formula	C₁₂H₁₁F₃O₃
Molecular Weight	260.21 g/mol
Synonyms	Ethyl 3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate; Ethyl 2-Trifluoromethylbenzoylacetate; 3-Oxo-3-(o-trifluoromethylphenyl)propionic Acid Ethyl Ester; 2-(Trifluoromethyl)benzoylacetic Acid Ethyl Ester; Ethyl (2-Trifluoromethylbenzoyl)acetate; o-Trifluoromethylbenzoylacetic Acid Ethyl Ester; TFMPAA Ethyl Ester; 89424-17-9
EINECS	Contact for details

Quality Control

Our 3-Oxo-3-(2-Trifluoromethylphenyl)Propionic Acid Ethyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.