Description

Atriopeptin I (Rat) is a specific, biologically active peptide fragment derived from rat atrial natriuretic peptide (ANP). This compound is a critical research tool for investigating the cardiovascular and renal regulatory functions of the natriuretic peptide system. It is primarily utilized by pharmaceutical researchers, academic institutions, and contract research organizations (CROs) engaged in cardiovascular disease, hypertension, and renal physiology studies. The product, identified by CAS No. 89139-53-7, is supplied to meet the stringent demands of preclinical and biochemical research.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of atrial natriuretic peptide (ANP) receptor binding and signal transduction pathways.
• Cardiovascular Pharmacology: Employed in in vitro and in vivo models to study vasodilation, blood pressure regulation, and cardiac function.
• Renal Physiology Studies: Applied in research investigating natriuresis, diuresis, and the regulation of electrolyte and fluid balance by the kidneys.
• Enzyme Substrate: Serves as a specific substrate for studying the activity and inhibition of proteolytic enzymes like neprilysin that metabolize ANP.
• Antibody Production & Immunoassay Development: Used as an immunogen for generating specific antibodies or as a calibrator in ELISA and RIA kits.
• Cell Culture & Molecular Biology: Utilized in cell-based assays to examine gene expression and cellular responses modulated by natriuretic peptides.

Basic Information

Product Name	Atriopeptin I (Rat)
CAS No.	89139-53-7
Molecular Formula	C106H166N36O31S2
Molecular Weight	2476.8 g/mol
Synonyms	Atrial Natriuretic Peptide (5-25) (rat); ANP (5-25); Atriopeptin I; Cardionatrin I (rat); rANP (5-25); H-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: Cys7-Cys23)
EINECS	Contact for details

Quality Control

Our Atriopeptin I (Rat) is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, critical for reproducible research outcomes. Each lot undergoes rigorous analytical testing including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.