Description

Pamidronicacidmonosodiumsalt CAS NO 89131-02-2 is the monosodium salt form of pamidronic acid, a second-generation bisphosphonate compound. This high-purity active pharmaceutical ingredient (API) is critical for the formulation of effective bone resorption inhibitors. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for conditions like osteoporosis, Paget's disease, and hypercalcemia of malignancy. Our product is supplied under strict quality control to ensure consistency and efficacy in final drug formulations.

Application

• Pharmaceutical API: Primary active ingredient in injectable formulations for the treatment of osteoporosis and bone metastases.
• Bone Resorption Inhibitor: Used in medications to prevent bone loss and reduce the risk of fractures in postmenopausal women and patients on long-term corticosteroid therapy.
• Oncological Support: Key component in therapies for managing hypercalcemia (high blood calcium levels) associated with cancers such as multiple myeloma and breast cancer.
• Paget's Disease Treatment: Formulated into drugs that help control the excessive bone breakdown and formation characteristic of this chronic bone disorder.
• Research & Development: Serves as a reference standard and starting material in preclinical and clinical research for new bone-targeting therapeutics.
• Veterinary Medicine: Potential application in treating similar bone disorders in animals.

Basic Information

Product Name	Pamidronicacidmonosodiumsalt
CAS No.	89131-02-2
Molecular Formula	C3H8NNaO7P2
Molecular Weight	255.03 g/mol
Synonyms	Pamidronate Monosodium Salt; Pamidronic Acid Monosodium Salt; Sodium Pamidronate; (3-Amino-1-hydroxypropylidene)bisphosphonic Acid Monosodium Salt; APD Monosodium Salt; Aminohydroxypropylidene Bisphosphonate Monosodium; CGP 23339A; Aredia (Brand Name API Component)
EINECS	Contact for details

Quality Control

Our Pamidronicacidmonosodiumsalt is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure identity, purity, strength, and composition. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological limits. Production can be aligned with current Good Manufacturing Practice (cGMP) guidelines for API manufacture upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
pH (1% Solution)	6.0 - 8.0
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 1.0 EU/mg (for injectable grade)
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.