Description

1,25-Dihydroxy-19-Norvitamin D3 is a synthetic analog of the active form of vitamin D, designed for enhanced biological activity and research utility. This compound is critical for investigating calcium and phosphate metabolism, cell differentiation, and immune modulation pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and manufacturers of high-purity biochemical reagents.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutics for osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Biochemical Research: Used as a potent ligand to study the vitamin D receptor (VDR) signaling pathway, gene expression, and mechanisms of action in various cell lines and animal models.
• Reference Standard: Serves as a high-purity calibration standard in analytical laboratories for method development and quality control of related vitamin D analogs.
• Nutritional Science Studies: Employed in preclinical studies to understand the effects of vitamin D analogs on bone mineral density and metabolic functions.

Basic Information

Product Name	1,25-Dihydroxy-19-Norvitamin D3
CAS No.	130447-37-9
Molecular Formula	C₂₆H₄₄O₃
Molecular Weight	404.63 g/mol
Synonyms	19-Nor-1,25-dihydroxyvitamin D3; 1,25-Dihydroxy-19-nor-cholecalciferol; 19-Nor-1α,25-dihydroxyvitamin D3; 1α,25-Dihydroxy-19-norvitamin D3; Paricalcitol Impurity/Intermediate; Zemplar Impurity; 19-Nor-1α,25-(OH)₂D₃
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-19-Norvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and degradation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.