Description

Disodium Pamidronate is a high-purity bisphosphonate compound, essential for its potent ability to inhibit osteoclast-mediated bone resorption. This makes it a critical active pharmaceutical ingredient (API) for the formulation of effective treatments for bone disorders such as osteoporosis, Paget's disease, and hypercalcemia of malignancy. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of injectable therapeutics. Disodium Pamidronate CAS NO 109552-15-0 is supplied under stringent quality control to ensure reliability for sensitive medical applications.

Application

• Primary Active Pharmaceutical Ingredient (API) in injectable formulations for treating osteoporosis and Paget's disease of bone.
• Key therapeutic agent for managing hypercalcemia (high blood calcium levels) associated with malignancy.
• Research and development of novel bone-targeted drug delivery systems and combination therapies.
• Reference standard in analytical laboratories for quality control and method validation of pamidronate-based pharmaceuticals.
• Starting material for the synthesis of more complex bisphosphonate derivatives in medicinal chemistry.
• Component in non-clinical studies investigating bone metabolism and pathology.

Basic Information

Product Name	Disodium Pamidronate
CAS No.	109552-15-0
Molecular Formula	C3H9NNa2O7P2
Molecular Weight	279.03 g/mol
Synonyms	Pamidronate Disodium; Disodium (3-Amino-1-hydroxypropylidene)bisphosphonate; APD; Aminohydroxypropylidene Bisphosphonate Disodium; Pamidronic Acid Disodium Salt; Aredia (Brand Name API); CGP 23339; Disodium Pamidronate Pentahydrate
EINECS	Contact for details

Quality Control

Our Disodium Pamidronate is manufactured and tested to meet exacting standards suitable for pharmaceutical applications. Quality assurance includes compliance with relevant sections of USP/EP monographs where applicable. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure traceability and supply chain integrity in line with GMP principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
pH (1% Solution)	7.5 - 9.0
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.