Description

Minodronate is a potent third-generation bisphosphonate compound, recognized for its high affinity for bone hydroxyapatite and its role in modulating bone metabolism. This active pharmaceutical ingredient (API) is critical for the development of targeted therapies for metabolic bone disorders, offering significant value in the pharmaceutical supply chain. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the formulation of treatments for osteoporosis and other conditions involving excessive bone resorption.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of osteoporosis medications.
• Key component in pharmaceutical research for bone-related metabolic diseases.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Intermediate in the synthesis of more complex bisphosphonate derivatives for clinical studies.
• Used in preclinical and clinical research to investigate its efficacy and safety profiles.

Basic Information

Product Name	Minodronate
CAS No.	127657-42-5
Molecular Formula	C9H12NNaO7P2 • xH2O
Molecular Weight	Anhydrous Free Acid: 291.14 g/mol
Synonyms	Minodronic Acid; Minodronate Monohydrate; YM-529; (1-Hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bisphosphonic Acid; Minodronate Sodium; ONO-5920; Minodronate Hydrate; Minodronate (YM529)
EINECS	Contact for details

Quality Control

Our Minodronate is produced under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing the results against relevant specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.