Description

Clodronic Acid is a first-generation bisphosphonate compound, a class of chemicals known for their strong affinity for bone mineral. This high-purity active pharmaceutical ingredient (API) is critical for developing and manufacturing effective treatments for bone resorption disorders. It is primarily utilized by the pharmaceutical industry for the production of osteoporosis medications and other therapeutics targeting skeletal health. Our supply of Clodronic Acid CAS NO 10596-23-3 ensures the stringent quality and consistency required for advanced pharmaceutical applications.

Application

• Pharmaceutical API: Primary active ingredient in prescription medications for osteoporosis and Paget's disease of bone.
• Bone Metastasis Treatment: Used in formulations to manage hypercalcemia of malignancy and reduce skeletal complications in cancer patients.
• Research & Development: Key reference standard and building block in biochemical and pharmacological research on bone metabolism.
• Veterinary Medicine: Employed in treatments for skeletal disorders in companion and large animals.
• Formulation Development: Serves as a model compound for developing novel oral, intravenous, or topical bisphosphonate delivery systems.

Basic Information

Product Name	Clodronic Acid
CAS No.	10596-23-3
Molecular Formula	CCl2H4O6P2
Molecular Weight	244.91 g/mol
Synonyms	Clodronate; Dichloromethylene Bisphosphonic Acid; Clodronic Acid Disodium Salt (Hydrate); Methylenechlorophosphonate; (Dichloromethylene)bisphosphonic Acid; Bonefos; Loron; Ostac; Cl2MBP
EINECS	234-206-6

Quality Control

Our Clodronic Acid is manufactured and tested under a strict quality management system. Each batch is subjected to comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopoeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Chloride Content	Conforms
pH (1% Solution)	2.0 - 4.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.