Description

Methyl-4,4-Difluoroacetoacetate (Medfaa) is a versatile fluorinated building block essential for the synthesis of complex organic molecules. Its value lies in the introduction of the difluoroacetyl moiety, which can significantly alter the biological activity, metabolic stability, and physical properties of target compounds. This high-purity intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing difluoromethyl ketone or heterocyclic motifs.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the fluorine atoms enhance efficacy and environmental stability.
• Fluorinated Material Development: Serves as a monomer or modifier in the production of specialty polymers, coatings, and liquid crystals with unique performance characteristics.
• Organic Synthesis Reagent: A valuable reagent for constructing complex molecular architectures in academic and industrial research laboratories.
• Chemical Biology Probes: Employed in the development of fluorinated probes and tags for studying biological systems and drug-target interactions.

Basic Information

Product Name	Methyl-4,4-Difluoroacetoacetate (Medfaa)
CAS No.	89129-66-8
Molecular Formula	C5H6F2O3
Molecular Weight	152.10 g/mol
Synonyms	Methyl 4,4-difluoro-3-oxobutanoate; 4,4-Difluoroacetoacetic Acid Methyl Ester; Methyl 4,4-Difluoroacetoacetate; Medfaa; 3-Oxobutanoic acid, 4,4-difluoro-, methyl ester; Difluoroacetoacetic Acid Methyl Ester; Methyl 4,4-Difluoro-3-oxobutyrate
EINECS	Contact for details

Quality Control

Our Methyl-4,4-Difluoroacetoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.