Description

Atriopeptin 21 is a synthetic peptide fragment corresponding to the biologically active core of Atrial Natriuretic Peptide (ANP). This compound is a critical research tool for studying cardiovascular physiology, renal function, and natriuretic peptide receptor signaling pathways. It is essential for pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on hypertension, heart failure, and related metabolic disorders. Atriopeptin 21 CAS NO 89106-96-7 is supplied as a high-purity, lyophilized powder for reliable and reproducible experimental results.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of natriuretic peptide receptors (NPR-A, NPR-C) and their downstream signaling cascades.
• Cardiovascular Pharmacology: Employed in in vitro and in vivo models to investigate vasodilation, blood pressure regulation, and cardiac remodeling.
• Renal Physiology Studies: Applied in research on natriuresis, diuresis, and the regulation of sodium and water balance by the kidneys.
• Assay Development & Validation: Serves as a critical calibrant and control in the development of immunoassays (ELISA, RIA) for ANP detection.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel agonists or antagonists of the ANP pathway.
• Academic & Clinical Research: Supports fundamental research into the role of ANP in conditions like congestive heart failure, atherosclerosis, and electrolyte disorders.

Basic Information

Product Name	Atriopeptin 21
CAS No.	89106-96-7
Molecular Formula	C106H166N36O33S4
Molecular Weight	2476.9 g/mol
Synonyms	Atrial Natriuretic Peptide (7-28); ANP (7-28); Atriopeptin I (7-28); hANP (7-28); Cardionatrin I (7-28); Auriculin A (7-28); Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23)
EINECS	Contact for details

Quality Control

Our Atriopeptin 21 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and biological activity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC for purity assessment, Mass Spectrometry (MS) for identity confirmation, and Amino Acid Analysis (AAA). The product is suitable for research use and is supplied with guaranteed high purity (>95%).

Storage

Preserve in a tightly closed container, protected from light. Store the lyophilized powder at -20°C or below in a dry environment. For long-term storage, consider temperatures of -70°C to -80°C. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. Reconstituted solutions should be aliquoted and stored at -20°C or lower, and used promptly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	> 95.0%
Peptide Content	> 80% (by AAA)
Single Impurity (HPLC)	< 1.0%
Water Content (KF)	< 5.0%
Acetate Content (HPLC)	< 10.0%
Biological Activity	Assessed by receptor binding or functional assay (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.