Description

Desmethyl Fluvoxamine β-D-Glucuronide is a key metabolite of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine. This compound is of significant value in pharmaceutical research and development, particularly for metabolic profiling, pharmacokinetic studies, and as a reference standard in bioanalytical assays. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories involved in drug development, forensic toxicology, and clinical research to ensure accurate quantification and understanding of drug metabolism.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification of fluvoxamine and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance rates, and bioavailability of fluvoxamine.
• Bioanalytical Method Development & Validation: Serves as a critical calibrator and quality control sample in LC-MS/MS and HPLC methods for therapeutic drug monitoring (TDM).
• Forensic and Clinical Toxicology: Employed in assays to confirm fluvoxamine use or overdose in forensic investigations and clinical settings.
• Impurity Profiling: Used in the identification and characterization of related substances in fluvoxamine active pharmaceutical ingredient (API) manufacturing.
• Academic and Institutional Research: Supports fundamental research on SSRI pharmacology, glucuronidation processes, and neuropsychiatric drug interactions.

Basic Information

Product Name	Desmethyl Fluvoxamine β-D-Glucuronide
CAS No.	89103-66-2
Molecular Formula	C18H25FN2O8
Molecular Weight	416.40 g/mol
Synonyms	Fluvoxamine Metabolite; 5-Methoxy-4'-(trifluoromethyl)valerophenone O-Desmethyl Glucuronide; Norfluoxetine Glucuronide (related context); Fluvoxamine N-Desmethyl Glucuronide; Fluvoxamine Acid Glucuronide; DU 24565 Glucuronide; (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our Desmethyl Fluvoxamine β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.