Description

Demethyl Isradipine is a key pharmaceutical intermediate and a derivative of the calcium channel blocker Isradipine. This compound is essential for research and development in cardiovascular pharmacology, serving as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on developing and producing advanced cardiovascular therapeutics.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of Isradipine and related dihydropyridine calcium channel blockers.
• Research & Development: Critical for pharmacological studies exploring structure-activity relationships (SAR) of calcium antagonists.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in API manufacturing.
• Process Chemistry: Used in the development and optimization of scalable synthetic routes for cardiovascular drugs.
• Academic Research: Employed in university and institutional labs for studying vascular smooth muscle function and hypertension models.
• Custom Synthesis: A starting material for the preparation of novel, patent-protected derivatives with potential therapeutic applications.

Basic Information

Product Name	Demethyl Isradipine
CAS No.	88977-30-4
Molecular Formula	C18H20N2O5
Molecular Weight	344.36 g/mol
Synonyms	4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Methyl 1-Methylethyl Ester; Isradipine Impurity; Desmethyl Isradipine; PN 200-110 Derivative; (Isopropyl Methyl 4-(2,1,3-Benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate)
EINECS	Contact for details

Quality Control

Our Demethyl Isradipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.