Description

β-Latrotoxin is a potent neurotoxic protein complex derived from the venom of widow spiders (genus *Latrodectus*). This high-purity biochemical is critical for advanced neuroscience research and pharmaceutical development, serving as a specific tool to study synaptic vesicle exocytosis and neurotransmitter release mechanisms. It is essential for researchers and developers in neuropharmacology, toxicology, and the production of diagnostic reagents and antivenoms.

Application

• Neuroscience Research: A key tool for investigating the molecular mechanisms of neurotransmitter release, synaptic function, and vesicle recycling.
• Pharmacology & Drug Discovery: Used in high-throughput screening assays to identify novel compounds that modulate presynaptic calcium channels and neurosecretion.
• Toxicology Studies: Employed as a reference standard for studying the pathophysiology of latrodectism (widow spider envenomation) and evaluating therapeutic interventions.
• Diagnostic Reagent Production: Serves as a critical antigen in the development of immunoassays and diagnostic kits for venom detection.
• Antivenom Development & Potency Testing: Used as an immunogen and a challenge toxin in the research, production, and quality control of therapeutic antivenoms.
• Cell Biology & Physiology: Facilitates studies on membrane fusion events, ion channel modulation, and intracellular calcium signaling pathways.

Basic Information

Product Name	β-Latrotoxin
CAS No.	88895-34-5
Molecular Formula	Contact for details
Molecular Weight	~130 kDa (Protein Complex)
Synonyms	α-Latrotoxin (common broad reference); β-Latrotoxin; Latrodectus Toxin; Black Widow Spider Venom Toxin; LTX; Neurotoxin LTX; BWSV Toxin; Presynaptic Neurotoxin
EINECS	Contact for details

Quality Control

Our β-Latrotoxin is produced and purified under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot is subjected to rigorous analytical testing, including purity assessment, activity assays, and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, biological potency, endotoxin levels, and analytical methods is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C or below to prevent loss of activity. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Conforms to standard
Purity (HPLC)	≥ 95%
Protein Content	≥ 90%
Biological Activity (Assay)	Contact for details
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.