Description

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucyl-L-leucine is a high-purity, protected dipeptide building block essential for advanced peptide synthesis. This compound matters because it provides the critical stereochemical control and chemical functionality required for constructing complex peptide sequences with high fidelity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds. Its reliable quality ensures reproducible results in demanding synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the sequential assembly of peptide chains on resin.
• Solution-Phase Peptide Synthesis: For the construction of peptide fragments in solution, particularly for longer or more complex sequences.
• Pharmaceutical Research & Development: Serving as a critical intermediate in the discovery and development of peptide-based active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Used to introduce specific structural motifs, such as the branched side chain from leucine/isoleucine analogs, into designed molecules that mimic peptides.
• Bioconjugation and Labeling: The carboxylic acid group allows for further functionalization and conjugation to other molecules, carriers, or labels.
• Combinatorial Chemistry Libraries: As a building block for creating diverse libraries of peptide-like compounds for high-throughput screening.

Basic Information

Product Name	N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucyl-L-leucine
CAS No.	88743-98-0
Molecular Formula	C27H34N2O5
Molecular Weight	466.57 g/mol
Synonyms	Fmoc-L-Leu-L-Leu-OH; Fmoc-Leu-Leu-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucyl-L-leucine; Fmoc-Leu-Leu; Fmoc-L-Leu-L-Leu; Nα-Fmoc-L-leucyl-L-leucine; (2S)-2-[[(2S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-4-methylpentanoyl]amino]-4-methylpentanoic acid; Fmoc-LL-OH
EINECS	Contact for details

Quality Control

Our N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucyl-L-leucine is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to meet exacting standards. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.