Description

(R)-Phenylephrine-D3 is a deuterium-labeled isotopologue of the well-known α-1 adrenergic receptor agonist, (R)-Phenylephrine. This stable isotope-labeled compound is a critical tool for quantitative bioanalytical research, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on analytical method development, drug metabolism and pharmacokinetics (DMPK), and clinical research.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a high-purity, non-interfering internal standard for the accurate quantification of (R)-Phenylephrine in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in tracer studies to investigate the metabolic pathways, bioavailability, and clearance rates of phenylephrine in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Essential for developing and validating robust, sensitive, and specific analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Enables precise measurement of drug concentration over time, critical for building accurate PK/PD models.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports studies requiring precise measurement of phenylephrine levels in patients.
• Forensic and Doping Control Analysis: Used as a reference standard in forensic toxicology and anti-doping laboratories for the definitive identification and quantification of phenylephrine.

Basic Information

Product Name	(R)-Phenylephrine-D3
CAS No.	88694-06-8
Molecular Formula	C9H10D3NO2
Molecular Weight	170.22 g/mol (approx.)
Synonyms	(R)-(-)-Phenylephrine-d3; (1R)-2-(Methyl-d3-amino)-1-(3-hydroxyphenyl)ethanol; L-Phenylephrine-d3; (-)-Phenylephrine-d3; (R)-3-Hydroxy-α-[(methyl-d3-amino)methyl]benzenemethanol; m-Hydroxy-α-[(methyl-d3-amino)methyl]benzyl alcohol (R)-; Deuterated (R)-Phenylephrine; Phenylephrine Internal Standard
EINECS	Contact for details

Quality Control

Our (R)-Phenylephrine-D3 is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We support research compliance with standards relevant to pharmaceutical analysis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.