Description

n-Desmethylamifloxacin CAS NO 88569-57-7 is a key pharmaceutical intermediate and metabolite of the fluoroquinolone antibiotic amifloxacin. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel antibacterial agents. It is primarily required by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers engaged in the production of advanced antibiotic compounds and their related metabolites.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of fluoroquinolone antibiotic derivatives and related compounds.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies for the identification and quantification of amifloxacin metabolites in biological matrices.
• Pharmacokinetic & Metabolic Research: Essential for conducting ADME (Absorption, Distribution, Metabolism, and Excretion) studies to understand the metabolic pathways of amifloxacin.
• Quality Control & Method Development: Employed in pharmaceutical quality control laboratories for developing and validating HPLC, LC-MS, or other chromatographic methods.
• Impurity Profiling: Used to identify and control potential degradation products or process-related impurities in amifloxacin API (Active Pharmaceutical Ingredient) manufacturing.
• Biochemical Research: Applied in studies investigating the mechanism of action and bacterial resistance profiles of fluoroquinolone antibiotics.

Basic Information

Product Name	n-Desmethylamifloxacin
CAS No.	88569-57-7
Molecular Formula	C16H19FN4O3
Molecular Weight	334.35 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid; Amifloxacin Desmethyl Metabolite; Desmethylamifloxacin; Amifloxacin Impurity; Amifloxacin Related Compound; 6-Fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-1-cyclopropyl-3-quinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our n-Desmethylamifloxacin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing the results against agreed specifications. Our quality commitment ensures material suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.