Description

H-Cys(Acm)-Nh2 Hcl is a protected cysteine derivative, specifically the hydrochloride salt of S-acetamidomethyl-L-cysteine amide. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it provides a method to protect the thiol group of cysteine from unwanted side reactions during chain assembly. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the production of therapeutic peptides, peptide hormones, and biochemical research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid derivative for the controlled incorporation of cysteine residues into peptide sequences.
• Pharmaceutical Intermediates: Used in the synthesis of peptide-based active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Bioconjugation & Protein Engineering: Serves as a precursor for introducing thiol-reactive handles or for forming disulfide bonds in engineered proteins and antibody-drug conjugates (ADCs).
• Biochemical Research: Employed in academic and industrial labs for studying protein folding, structure-activity relationships (SAR), and enzyme mechanisms.
• Production of Cysteine-Containing Peptides: Essential for manufacturing peptides like glutathione, oxytocin, vasopressin, and other cysteine-rich bioactive molecules.

Basic Information

Product Name	H-Cys(Acm)-Nh2 Hcl
CAS No.	88530-32-9
Molecular Formula	C6H14ClN3O2S
Molecular Weight	227.71 g/mol
Synonyms	S-Acetamidomethyl-L-cysteine amide hydrochloride; L-Cysteine, S-(acetamidomethyl)-, amide, hydrochloride; Acm-Cys-NH2·HCl; H-Cys(Acm)-NH2·HCl; Cys(Acm) amide hydrochloride; N-[(R)-2-Amino-2-carbamoylethyl]-S-(acetamidomethyl)cysteamine hydrochloride; (2R)-2-Amino-3-[[2-(acetylamino)ethyl]sulfanyl]propanamide hydrochloride
EINECS	Contact for details

Quality Control

Our H-Cys(Acm)-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.