Description

Aldoamanitin is a highly specific and potent cyclic peptide toxin, primarily known for its role as a selective inhibitor of RNA polymerase II. This compound is of critical importance in biochemical and pharmacological research for studying eukaryotic transcription mechanisms and apoptosis pathways. It is an essential tool for researchers and developers in the fields of molecular biology, toxicology, and targeted therapeutic discovery, where precise enzyme inhibition is required.

Application

• Biochemical Research: Used as a selective inhibitor to study the function and mechanism of RNA polymerase II in eukaryotic cells.
• Apoptosis Studies: Employed in laboratory settings to induce programmed cell death and investigate related signaling pathways.
• Toxicology & Mechanism of Action: Serves as a reference standard and model toxin for understanding the effects of amatoxins.
• Pharmaceutical Development: Utilized in screening assays and research for developing novel transcription-targeting therapies.
• Diagnostic Tool Development: Acts as a key component in the development of assays for detecting amatoxin poisoning.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes focusing on gene expression regulation.

Basic Information

Product Name	Aldoamanitin
CAS No.	88498-52-6
Molecular Formula	C₃₉H₅₄N₁₀O₁₃S
Molecular Weight	918.98 g/mol
Synonyms	α-Amanitin, α-Amanitin; Amaninamide; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(2S)-2-Amino-2-carboxyethyl]-33-[(1R)-1-carboxy-2-(methylsulfanyl)ethyl]-3,6,9,12,15,18,21,24-octaoxo-1,4,7,10,13,16,19,22,25,28-decaazacyclotritriacontane-12-carboxylic acid; NSC 213759; Amatoxin; Cyclic peptide toxin from Amanita phalloides
EINECS	Contact for details

Quality Control

Our Aldoamanitin is produced and handled under strict quality protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support your compliance needs in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.