Description

L-1-Boc-Nipecotic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of central nervous system (CNS) targeting drugs and other therapeutic agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the nipecotic acid moiety into peptide chains under Boc-protection strategies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the creation of focused compound libraries.
• GABA Analogue Development: Fundamental starting material for synthesizing analogs of γ-Aminobutyric acid (GABA) for neurological research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules at various scales.
• Academic Research: Employed in university and institutional labs for methodological development in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	L-1-Boc-Nipecotic Acid
CAS No.	88495-54-9
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(3S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic Acid; (S)-1-Boc-Nipecotic Acid; (S)-1-(tert-Butoxycarbonyl)nipecotic Acid; (S)-1-Boc-3-piperidinecarboxylic Acid; (S)-3-Carboxy-1-N-Boc-piperidine; L-N-Boc-Nipecotic Acid; (S)-N-Boc-Nipecotic Acid; tert-Butyl (3S)-3-carboxypiperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our L-1-Boc-Nipecotic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.