Description

Des-Tyr-1-Leucine Enkephalin Acetate is a synthetic peptide analog of the endogenous opioid peptide enkephalin, modified to enhance its stability and research utility. This compound is a critical tool in neuroscience and pharmacology for studying opioid receptor interactions, signal transduction, and pain modulation pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neurobiology and analgesic drug discovery.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies of opioid receptor (primarily δ-opioid receptor) binding, activation, and downstream cellular effects.
• Pharmacological Assays: Serves as a key ligand in competitive binding assays and functional tests (e.g., cAMP inhibition, GTPγS binding) to screen and characterize novel opioid compounds.
• Biochemical Studies: Employed to investigate the structure-activity relationships (SAR) of enkephalin peptides and the metabolic pathways of neuropeptides.
• Drug Discovery: Acts as a starting point or intermediate in the design and synthesis of new peptide-based analgesics with potentially improved profiles.
• Cell Signaling Research: Applied in vitro to study the effects of opioid receptor stimulation on neuronal cell lines and primary cultures.

Basic Information

Product Name	Des-Tyr-1-Leucine Enkephalin Acetate
CAS No.	88492-45-9
Molecular Formula	C27H43N5O7 • xC2H4O2
Molecular Weight	549.66 g/mol (free base)
Synonyms	Des-Tyrosine-Leucine Enkephalin Acetate; [Leu]Enkephalin, Des-Tyr-1-; H-Leu-Phe-Leu-OH acetate; Leu-Phe-Leu tripeptide acetate; δ-opioid receptor peptide ligand; Opioid peptide fragment; YGGFLL (one-letter code, Des-Tyr-1) acetate salt
EINECS	Contact for details

Quality Control

Our Des-Tyr-1-Leucine Enkephalin Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Peptide Content (AAA)	≥ 80.0%
Acetate Content (IC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.